Turk J Hematol: 30 Side bay osman eskort Volume: 30 Issue: 3 - Multiple myeloma is the second most common haematological malignancy. Novel therapies have led to improvement in survival. Current myeloma management is matching the progress made in improved survival through disease control while optimising quality of life with effective supportive care. The aim of this review is to highlight the relationship among life of quality, supportive care, and improvement in survival. The clinical outcomes and survival of tyrosine kinase inhibitor TKI -treated patients with chronic myeloid leukemia CML have been significantly improved. The aim of this editorial is to outline critical steps of TKI administration practices during the long-term clinical course of CML based on data obtained from randomized clinical trials and international recommendations. The efficacy of TKI treatment, TKI side effects, off-target complications, and long-term morbidities due to both the disease and the drug are common arguments in the management of CML. Complete hematological response, early complete cytogenetic response, faster major molecular response, and deeper, more durable molecular responses MR4, MR4. While multipotent mesenchymal stromal cells MSCs demonstrate alloresponse in vitro and in vivo, they also have clinical applications toward prevention or treatment of GVHD. A total of 49 rats were randomly assigned to 4 study and 3 control groups administered different GVHD prophylactic regimens including MSCs. After transplantation, clinical GVHD scores and survival status were monitored. Objective: The expression of the tumor necrosis factor-related apoptosis-inducing ligand TRAIL protein and its regulation by chemotherapeutics were analyzed in primary acute leukemic cells. Materials and Methods: Peripheral blood was collected from 16 patients with acute leukemia on days 0, 1, 3, and 5 of chemotherapy. The mononuclear cells were separated from the peripheral blood, and TRAIL expression was assessed by flow cytometry. Results: TRAIL expression in the mononuclear cells of peripheral blood was significantly upregulated on day 1 p 0. Conclusion: OA single chemotherapy mechanism for leukemia may suffice to induce TRAIL expression and promote the apoptosis of leukemic cells. Objective: Fertility preservation stands before us as an issue of quality of life for cancer patients and their partners and families. Therefore, the object of the present study was to determine the extent of the knowledge that hematologists have about fertility preservation and to understand their attitudes and practices regarding this matter. Materials and Methods: A total of 25 hematologists participated in a survey. The questionnaire included questions on sociodemographic characteristics and awareness concerning the subject of fertility preservation, as well as questions designed to determine the extent of the knowledge that hematologists had on the subject and to understand their attitudes and practices in this context. All of the participants in the survey supported the idea of the Turkish Society of Hematology publishing a guidebook on this subject and organizing a session on fertility preservation in their regular congress. Conclusion: Meeting the needs of hematologists for training and knowledge in the subject of fertility preservation and ensuring the development of appropriate attitudes and practices in this area is an important issue. The Turkish Society of Hematology may play a significant key role. Objective: Diffuse large B-cell lymphoma DLBCL is a high-grade neoplasm Side bay osman eskort has heterogeneous properties in clinical, morphological, and immunophenotypic aspects. In the present study the effects of p53, Bcl-2, and Ki67 on prognosis and their relationships with clinical parameters were examined. The Ann Arbor classification system was used to determine the stage of the patients. The patients were evaluated according to age, sex, stage, B symptoms, extranodal involvement, and lactate dehydrogenase LDH level as well as immunohistochemically. P53 protein and Bcl-2 oncoprotein expressions and Ki67 proliferation index were assessed immunohistochemically. Results: High Bcl-2 expression was found in 9 patients Our results revealed that Bcl-2 and p53 protein expressions and Ki67 proliferation index have no effect on overall survival of patients with DLBCL. Conclusion: The prognostic importance of p53 and Bcl-2 protein expressions and Ki67 proliferation index in DLBCL, which has biological and clinical heterogeneity, can be understood in a large series of studies that have subclasses and immunohistochemical markers with optimal cut-off values. Objective: Cardiac failure due to iron overload remains the most common cause of death in patients with beta-thalassemia major. This study aimed to evaluate myocardial function in children with beta-thalassemia major using standard echocardiography technique and strain rate imaging. However, the adulthood strain and strain rate imaging values may be lower than controls, exceeding the critical level of iron overload. Objective: Survival rates for childhood acute lymphoblastic leukemia ALL have significantly improved and late effects of therapy have been Side bay osman eskort in the follow-up of survivors. The objective of this study is to identify the endocrinological and cardiological late effects of ALL patients treated in our pediatric hematology unit. The study group was evaluated with anthropometric measurements, body mass index, and laboratory testing of fasting glucose, insulin, serum lipids, thyroid functions, and bone mineral densities. Echocardiography and pulsed wave Doppler imaging were performed for analysis of cardiac functions. Subjects who were overweight or obese at the time of diagnosis were more likely to be overweight or obese at last follow-up.
This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor. Objective: The expression of the tumor necrosis factor-related apoptosis-inducing ligand TRAIL protein and its regulation by chemotherapeutics were analyzed in primary acute leukemic cells. Işe girerken ve çalışma esnasında bayanların karşılaştığı mühim bir sorun da cinsi taciz.. However, the adulthood strain and strain rate imaging values may be lower than controls, exceeding the critical level of iron overload. Sallam , Manal A.
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